(19)

(11)

EP 1 268 804 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01916704.8 (22) Date of filing: 16.03.2001

(51) International Patent Classification (IPC)7: C12N 15/19, C07K 14/52, C12N 15/62, C12N 5/10, A01K 67/027, C12Q 1/68, G01N 33/68, C07K 16/24 (86) International application number: PCT/US0108/493 (87) International publication number: WO 0107/0986 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.03.2000 US 527843 25.04.2000 US 558459 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: CONKLIN, Darrell, C. Seattle, WA 98102 (US) PRESNELL, Scott, R. Tacoma, WA 98407 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)