(19)

(11)

EP 1 268 814 A2

(12)

(88) Date of publication A3: 28.02.2002 (43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01915412.9 (22) Date of filing: 23.03.2001

(51) International Patent Classification (IPC)7: C12N 15/55, C12N 9/48, C12N 5/10, C12Q 1/68, G01N 33/50, A61K 48/00, A61K 9/00 (86) International application number: PCT/EP0103/331 (87) International publication number: WO 0107/0997 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.03.2000 US 191716 P (71) Applicant: Bayer Aktiengesellschaft 51368 Leverkusen (DE)	(72) Inventors: RAMAKRISHNAN, Shyam Brighton, MA 02135 (US) XIAO, Yonghong Cambridge, MA 02138 (US)