| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
| (30) |
Priority: |
06.03.2000 US 186976 P 07.04.2000 US 195672 P
|
| (43) |
Date of publication of application: |
|
02.01.2003 Bulletin 2003/01 |
| (73) |
Proprietor: BioSeek LLC |
|
Burlingame, CA 94010 (US) |
|
| (72) |
Inventors: |
|
- BERG, Ellen, L.
Palo Alto, CA 94303 (US)
- BUTCHER, Eugene, C.
Portola Valley, CA 94025 (US)
- MELROSE, Jennifer
La Honda, CA 94020 (US)
- PLAVEC, Ivan
Sunnyvale, CA 94087 (US)
|
| (74) |
Representative: Brasnett, Adrian Hugh et al |
|
Mewburn Ellis LLP
33 Gutter Lane London
EC2V 8AS London
EC2V 8AS (GB) |
| (56) |
References cited: :
WO-A-01/40518 WO-A-96/23075 US-A- 5 601 981 US-A- 5 965 352
|
WO-A-95/06132 US-A- 5 569 588 US-A- 5 665 562 US-A- 5 981 472
|
|
| |
|
|
- MAY M J ET AL: "Effects of protein tyrosine kinase inhibitors on cytokine-induced
adhesion molecule expression by human umbilical vein endothelial cells" BRITISH JOURNAL
OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 118, no. 7, 1996, pages 1761-1771, XP002972511
ISSN: 0007-1188
- RICE J W ET AL: "Development of a high volume screen to identify inhibitors of endothelial
cell activation." ANALYTICAL BIOCHEMISTRY. 15 OCT 1996, vol. 241, no. 2, 15 October
1996 (1996-10-15), pages 254-259, XP002344528 ISSN: 0003-2697
- HAUSNER P ET AL: "THE COMPARATIVE GROWTH ASSAY:EXAMINING THE INTERPLAY OF ANTI-CANCER
AGENTS WITH CELLS CARRYING SINGLE GENE ALTERATIONS" NEOPLASIA, DOYMA, BARCELONA,,
ES, vol. 1, no. 4, October 1999 (1999-10), pages 356-367, XP002939327 ISSN: 0212-9787
- BHALLA U.S.; IYENGAR R.: "Emergent properties of networks of biological signaling
pathways" SCIENCE, vol. 283, no. 5400, 15 January 1999 (1999-01-15), pages 381-387,
NEW YORK, UNITED STATES
- LAVÉ T. ET AL: "The use of human hepatocytes to select compounds based on their expected
hepatic extraction ratios in humans" PHARMACEUTICAL RESEARCH, vol. 14, no. 2, February
1997 (1997-02), pages 152-155, UNITED STATES
- HUGHES T.R. ET AL: "Functional discovery via a compendium of expression profiles"
CELL, vol. 102, no. 1, 7 July 2000 (2000-07-07), pages 109-126, XP002225641 UNITED
STATES
- MARIADASON J.M. ET AL: "Genetic reprogramming in pathways of colonic cell maturation
induced by short chain fatty acids: comparison with trichostatin A, sulindac, and
curcumin and implications for chemoprevention of colon cancer" CANCER RESEARCH, vol.
60, no. 16, 15 August 2000 (2000-08-15), pages 4561-4572, XP002438262 UNITED STATES
- MARTON M.J. ET AL: "Drug target validation and identification of secondary drug target
effects using DNA microarrays" NATURE MEDICINE, vol. 4, no. 11, November 1998 (1998-11),
pages 1293-1301, XP002168523 UNITED STATES
- ROBERTS C.J. ET AL: "Signaling and circuitry of multiple MAPK pathways revealed by
a matrix of global gene expression profiles" SCIENCE, vol. 287, no. 5454, 4 February
2000 (2000-02-04), pages 873-880, XP008063512 UNITED STATES
- GRAY N.S. ET AL: "Exploiting chemical libraries, structure, and genomics in the search
for kinase inhibitors" SCIENCE, vol. 281, no. 5376, 24 July 1998 (1998-07-24), pages
533-538, XP000669510 UNITED STATES
- HELLER R.A. ET AL: "Discovery and analysis of inflammatory disease-related genes using
cDNA microarrays" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES
OF AMERICA, vol. 94, no. 6, 18 March 1997 (1997-03-18) , pages 2150-2155, XP002076789
UNITED STATES
|
|