(19)
(11) EP 1 269 187 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
05.10.2011 Bulletin 2011/40

(45) Mention of the grant of the patent:
13.07.2011 Bulletin 2011/28

(21) Application number: 01914718.0

(22) Date of filing: 06.03.2001
(51) International Patent Classification (IPC): 
G01N 33/53(2006.01)
G01N 33/50(2006.01)
G01N 33/567(2006.01)
G01N 33/68(2006.01)
(86) International application number:
PCT/US2001/007190
(87) International publication number:
WO 2001/067103 (13.09.2001 Gazette 2001/37)

(54)

FUNCTION HOMOLOGY SCREENING

SCREENING FÜR FUNKTIONSHOMOLOGIEN

CRIBLAGE D'HOMOLOGIE DE FONCTIONS


(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 06.03.2000 US 186976 P
07.04.2000 US 195672 P

(43) Date of publication of application:
02.01.2003 Bulletin 2003/01

(73) Proprietor: BioSeek LLC
Burlingame, CA 94010 (US)

(72) Inventors:
  • BERG, Ellen, L.
    Palo Alto, CA 94303 (US)
  • BUTCHER, Eugene, C.
    Portola Valley, CA 94025 (US)
  • MELROSE, Jennifer
    La Honda, CA 94020 (US)
  • PLAVEC, Ivan
    Sunnyvale, CA 94087 (US)

(74) Representative: Brasnett, Adrian Hugh et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
WO-A-01/40518
WO-A-96/23075
US-A- 5 601 981
US-A- 5 965 352
WO-A-95/06132
US-A- 5 569 588
US-A- 5 665 562
US-A- 5 981 472
   
  • MAY M J ET AL: "Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecule expression by human umbilical vein endothelial cells" BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 118, no. 7, 1996, pages 1761-1771, XP002972511 ISSN: 0007-1188
  • RICE J W ET AL: "Development of a high volume screen to identify inhibitors of endothelial cell activation." ANALYTICAL BIOCHEMISTRY. 15 OCT 1996, vol. 241, no. 2, 15 October 1996 (1996-10-15), pages 254-259, XP002344528 ISSN: 0003-2697
  • HAUSNER P ET AL: "THE COMPARATIVE GROWTH ASSAY:EXAMINING THE INTERPLAY OF ANTI-CANCER AGENTS WITH CELLS CARRYING SINGLE GENE ALTERATIONS" NEOPLASIA, DOYMA, BARCELONA,, ES, vol. 1, no. 4, October 1999 (1999-10), pages 356-367, XP002939327 ISSN: 0212-9787
  • BHALLA U.S.; IYENGAR R.: "Emergent properties of networks of biological signaling pathways" SCIENCE, vol. 283, no. 5400, 15 January 1999 (1999-01-15), pages 381-387, NEW YORK, UNITED STATES
  • LAVÉ T. ET AL: "The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans" PHARMACEUTICAL RESEARCH, vol. 14, no. 2, February 1997 (1997-02), pages 152-155, UNITED STATES
  • HUGHES T.R. ET AL: "Functional discovery via a compendium of expression profiles" CELL, vol. 102, no. 1, 7 July 2000 (2000-07-07), pages 109-126, XP002225641 UNITED STATES
  • MARIADASON J.M. ET AL: "Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer" CANCER RESEARCH, vol. 60, no. 16, 15 August 2000 (2000-08-15), pages 4561-4572, XP002438262 UNITED STATES
  • MARTON M.J. ET AL: "Drug target validation and identification of secondary drug target effects using DNA microarrays" NATURE MEDICINE, vol. 4, no. 11, November 1998 (1998-11), pages 1293-1301, XP002168523 UNITED STATES
  • ROBERTS C.J. ET AL: "Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles" SCIENCE, vol. 287, no. 5454, 4 February 2000 (2000-02-04), pages 873-880, XP008063512 UNITED STATES
  • GRAY N.S. ET AL: "Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors" SCIENCE, vol. 281, no. 5376, 24 July 1998 (1998-07-24), pages 533-538, XP000669510 UNITED STATES
  • HELLER R.A. ET AL: "Discovery and analysis of inflammatory disease-related genes using cDNA microarrays" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 6, 18 March 1997 (1997-03-18) , pages 2150-2155, XP002076789 UNITED STATES
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).