(19)

(11)

EP 1 272 513 A2

(12)

(88) Date of publication A3: 17.05.2001 (43) Date of publication: 08.01.2003 Bulletin 2003/02 (21) Application number: 00959962.2 (22) Date of filing: 07.09.2000

(51) International Patent Classification (IPC)7: C07K 14/47, C12N 15/12, C12N 15/10, C12N 15/63, A61K 38/17, A61P 25/28 (86) International application number: PCT/US0024/495 (87) International publication number: WO 0101/8043 (15.03.2001 Gazette 2001/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.09.1999 US 393433 (71) Applicant: Prolifia, Inc. Tucson, AZ 85711-3365 (US)	(72) Inventors: BOCK, Elisabeth,University of Copenhagen DK-2200 Copenhagen N (DK) LUKANIDIN, Eugene, M. DK-2100 Copenhagen O (DK) BEREZIN, Vladimir DK-2200 Copenhagen N (DK) (74) Representative: HOFFMANN EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)