(19)

(11)

EP 1 272 615 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 08.01.2003 Bulletin 2003/02 (21) Application number: 01926403.5 (22) Date of filing: 21.03.2001

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 5/02, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74, C12N 15/85, C12N 15/86, C12N 15/87, A01N 63/00, A61K 48/00 (86) International application number: PCT/US0109/101 (87) International publication number: WO 0107/0175 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.03.2000 US 191063 P (71) Applicant: THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION Charlottesville,VA 22903 (US)	(72) Inventors: CHUNG, Leland, W., K. Lovingston, VA 22949 (US) KAO, Chinghai Charlottesville, VA 22903 (US) GARDNER, Thomas, A. Zionsville, IN 46077 (US) KO, Song-Chu Charlottesville, VA 22901 (US) (74) Representative: Horner, Martin Grenville et al Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)