(19)
(11)
EP 1 274 857 A1
(12)
(43)
Date of publication:
15.01.2003
Bulletin 2003/03
(21)
Application number:
01918439.9
(22)
Date of filing:
08.03.2001
(51)
International Patent Classification (IPC)
7
:
C12P
21/00
,
A61K
31/00
,
A61K
49/00
,
A01N
43/04
(86)
International application number:
PCT/US0107/378
(87)
International publication number:
WO 0106/6784
(
13.09.2001
Gazette 2001/37)
(84)
Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI
(30)
Priority:
08.03.2000
US 187893 P
(71)
Applicant:
Sloan-Kettering InstituteFor Cancer Research
New York,New York 10021 (US)
(72)
Inventor:
BENEZRA, Robert
Hampton Bays, NY 11946 (US)
(74)
Representative:
Wallace, Sheila Jane et al
Lloyd WiseCommonwealth House,1-19 New Oxford Street
London WC1A 1LW
London WC1A 1LW (GB)
(54)
INHIBITOR OF DIFFERENTIATION KNOCKOUT MAMMALS AND METHODS OF USE THEREOF