(19)
(11) EP 1 274 857 A1

(12)

(43) Date of publication:
15.01.2003 Bulletin 2003/03

(21) Application number: 01918439.9

(22) Date of filing: 08.03.2001
(51) International Patent Classification (IPC)7C12P 21/00, A61K 31/00, A61K 49/00, A01N 43/04
(86) International application number:
PCT/US0107/378
(87) International publication number:
WO 0106/6784 (13.09.2001 Gazette 2001/37)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 08.03.2000 US 187893 P

(71) Applicant: Sloan-Kettering InstituteFor Cancer Research
New York,New York 10021 (US)

(72) Inventor:
  • BENEZRA, Robert
    Hampton Bays, NY 11946 (US)

(74) Representative: Wallace, Sheila Jane et al
Lloyd WiseCommonwealth House,1-19 New Oxford Street
London WC1A 1LW
London WC1A 1LW (GB)

   


(54) INHIBITOR OF DIFFERENTIATION KNOCKOUT MAMMALS AND METHODS OF USE THEREOF