(19)

(11)

EP 1 274 859 A1

(12)

(43) Date of publication: 15.01.2003 Bulletin 2003/03 (21) Application number: 00976987.8 (22) Date of filing: 06.11.2000

(51) International Patent Classification (IPC)7: C12Q 1/48, C12N 9/12, C12N 15/54 (86) International application number: PCT/US0030/542 (87) International publication number: WO 0103/2918 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 05.11.1999 US 163901 P 03.11.2000 US 706426 (71) Applicants: SmithKline Beecham Corporation Philadelphia, PA 19130 (US) SmithKline Beecham plc Brentford,Middlesex TW8 9GS (GB)	(72) Inventors: KASSIS, Shouki Audubon, PA 19403 (US) ANNAN, Roland, S. West Chester, PA 19382 (US) LEE, John, C. Indianapolis, IN 46260 (US) (74) Representative: Stott, Michael John  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)