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EP 1 276 716 A2

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(88) Date of publication A3: 28.03.2002 (43) Date of publication: 22.01.2003 Bulletin 2003/04 (21) Application number: 01924862.4 (22) Date of filing: 10.04.2001

(51) International Patent Classification (IPC)7: C07C 309/18, C07C 323/58, C07K 1/22 (86) International application number: PCT/US0111/529 (87) International publication number: WO 0108/1365 (01.11.2001 Gazette 2001/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.04.2000 US 558001 (71) Applicant: Sigma-Aldrich Company Highland,Illinois 62249 (US)

(72) Inventors: KAPPEL, William K.,c/o Sigma-Aldrich Co. St. Louis, MO 63178 (US) VISWANATHA, Venkatappa,c/o Sigma-Aldrich Co. St. Louis, MO 63178 (US) LI, Handong,c/o Sigma-Aldrich Co. St. Louis, MO 63178 (US) MEHIGH, Richard J.,c/o Sigma-Aldrich Co. St. Louis, MO 63178 (US) DAPRON, John G.,c/o Sigma-Aldrich Co. St. Louis, MO 63178 (US) (74) Representative: Maiwald, Walter, Dr. Dipl.-Chem. et al Maiwald Patentanwalts GmbHElisenhofElisenstrasse 3 80335 München 80335 München (DE)