(19)

(11)

EP 1 276 726 A2

(12)

(88) Date of publication A3: 23.05.2002 (43) Date of publication: 22.01.2003 Bulletin 2003/04 (21) Application number: 01932712.1 (22) Date of filing: 25.04.2001

(51) International Patent Classification (IPC)7: C07D 233/54, A61K 31/33, A61P 43/00, C07D 401/10, C07D 249/08, C07D 231/12, C07D 333/16, C07D 409/10, C07D 405/12, C07D 413/12, C07D 417/12, C07D 213/57, C07D 213/74, C07D 277/24, C07D 213/38, C07D 401/14, C07D 409/12 (86) International application number: PCT/US0113/678 (87) International publication number: WO 0108/1316 (01.11.2001 Gazette 2001/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.04.2000 US 563256 02.04.2001 US 822205 (71) Applicant: Abbott Laboratories Abbott Park,Illinois 60064-3500 (US)

(72) Inventors: WANG, Wei-Bo Grayslake, IL 60030 (US) CURTIN, Michael, L. Pleasant Prairie, WI 53158 (US) FAKHOURY, Stephen, A. Vernon Hills, IL 60061 (US) GWALTNEY, Stephen, L., II Lindenhurst, IL 60046 (US) HASVOLD, Lisa A. Grayslake, IL 60030 (US) HUTCHINS, Charles, W. Green Oaks, IL 60048 (US) LI, Qui Libertyville, IL 60061 (US) LIN, Nan-Horng Vernon Hills, IL 60061 (US) JENNINGS NELSON, Lissa, Taka Highland Park, IL 60035 (US) O'CONNOR, Stephen, J. Guilford, CT 06437 (US) SHAM, Hing, L. Vernon Hills, IL 60061 (US) SULLIVAN, Gerald, M. Round Lake Beach, IL 60073 (US) WANG, Gary, T. Niles, IL 60714 (US) WANG, Xilu Skokie, IL 60076 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)