(19)

(11)

EP 1 276 768 A2

(12)

(88) Date of publication A3: 23.05.2002 (43) Date of publication: 22.01.2003 Bulletin 2003/04 (21) Application number: 01932610.7 (22) Date of filing: 24.04.2001

(51) International Patent Classification (IPC)7: C07K 14/705, A61K 38/17, C12N 7/01, C12N 15/866, G01N 33/50, C12N 15/11, A61K 39/00, A61K 48/00 (86) International application number: PCT/US0113/053 (87) International publication number: WO 0108/1407 (01.11.2001 Gazette 2001/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.04.2000 US 199632 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: LIND, Peter S-751 29 Uppsala (SE) VOGELI, Gabriel Seattle, Washington 98119 (US) WOOD, Linda, S. Portage, MI 49024 (US) MERCHANT, Kalpana, M. Portage, MI 49024 (US) SODERBERG, Charlotte S-756 43 Uppsala (SE) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)