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(11)

EP 1 276 869 A2

(12)

(88) Date of publication A3: 07.02.2002 (43) Date of publication: 22.01.2003 Bulletin 2003/04 (21) Application number: 01942508.1 (22) Date of filing: 19.01.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/63, C12N 15/82, C12N 5/10, C12N 5/14, C07K 14/00, C07K 16/00, C07K 19/00, C12Q 1/68, A01H 5/00, A01H 5/10 (86) International application number: PCT/US0101/817 (87) International publication number: WO 0105/2620 (26.07.2001 Gazette 2001/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.01.2000 US 177468 P 21.07.2000 US 620897 (71) Applicants: The Scripps Research Institute La Jolla, CA 92037 (US) TORREY MESA RESEARCH INSTITUTE San Diego, CA 92121 (CA)	(72) Inventors: BARBAS, Carlos, F., III. Solana Beach, CA 92075 (US) STEGE, Justin, T. San Diego, CA 92126 (US) GUAN, Xueni San Diego, CA 92129 (US) DALMIA, Bipin San Diego, CA 92129 (US) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)