(19)
(11) EP 1 276 888 A2

(12)

(88) Date of publication A3:
13.06.2002

(43) Date of publication:
22.01.2003 Bulletin 2003/04

(21) Application number: 01926234.4

(22) Date of filing: 26.04.2001
(51) International Patent Classification (IPC)7C12N 15/86, C12N 15/10
(86) International application number:
PCT/NL0100/323
(87) International publication number:
WO 0108/1607 (01.11.2001 Gazette 2001/44)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 26.04.2000 US 200160 P

(71) Applicants:
  • Crucell Holland B.V.
    2333 CN Leiden (NL)
  • Vrije Universiteit Medisch Centrum (VUMC)
    1081 HV Amsterdam (NL)

(72) Inventors:
  • VAN ES, Helmuth, Hendrikus, Gerardus
    NL-2133 DJ Hoofddorp (NL)
  • VAN BEUSECHEM, Victor, Willem
    NL-1072 HE Amsterdam (NL)

(74) Representative: Prins, Adrianus Willem et al
Vereenigde,Nieuwe Parklaan 97
2587 BN Den Haag
2587 BN Den Haag (NL)

   


(54) ADENOVIRUS VECTORS WITH KNOBLESS FIBERS, AND THEIR USES