(19)

(11)

EP 1 278 502 A2

(12)

(88) Date of publication A3: 04.04.2002 (43) Date of publication: 29.01.2003 Bulletin 2003/05 (21) Application number: 01970508.6 (22) Date of filing: 17.04.2001

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US0112/326 (87) International publication number: WO 0108/9451 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.04.2000 US 198493 P 07.03.2001 US 273811 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)

(72) Inventors: CUMMINGS, Maxwell, D. Strafford, PA 19087 (US) MARQUIS, Robert, W., Jr. Wayne, PA 19087 (US) RU, Yu Wayne, PA 19087 (US) THOMPSON, Scott, K. Phoenixville, PA 19460 (US) VEBER, Daniel, F. Ambler, PA 19002 (US) YAMASHITA, Dennis, S. Wayne, PA 19087 (US) (74) Representative: Rutter, Keith et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)