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(11)

EP 1 278 746 A2

(12)

(88) Date of publication A3: 18.07.2002 (43) Date of publication: 29.01.2003 Bulletin 2003/05 (21) Application number: 01934990.1 (22) Date of filing: 02.05.2001

(51) International Patent Classification (IPC)7: C07D 471/14, A61K 31/4353, A61P 15/00, A61P 21/00, C07D 471/04, C07D 491/048, C07D 495/14, C07D 491/056 (86) International application number: PCT/US0114/164 (87) International publication number: WO 0108/3480 (08.11.2001 Gazette 2001/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 02.05.2000 US 563711 (71) Applicant: Abbott Laboratories Abbott Park, IL 60064-6050 (US)

(72) Inventors: CARROLL, William A. Evanston, IL 60201 (US) AGRIOS, Konstantinos A. Sand Diego, CA 92101 (US) BASHA, Fatima Z. Lake Forest, IL 60045 (US) CHEN, Yiyuan East Syracuse, NY 13057 (US) KORT, Michael E. Lake Bluff, IL 60044-1529 (US) KYM, Philip R. Grayslake, IL 60030 (US) TANG, Rui Gurnee, IL 60031 (US) TURNER, Sean C. Evanston, IL 60201 (US) YI, Lin Gurnee, IL 60031 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)