(19)

(11)

EP 1 278 773 A2

(12)

(88) Date of publication A3: 14.11.2002 (43) Date of publication: 29.01.2003 Bulletin 2003/05 (21) Application number: 00988723.3 (22) Date of filing: 17.11.2000

(51) International Patent Classification (IPC)7: C07K 14/705, G01N 33/566 (86) International application number: PCT/EP0011/474 (87) International publication number: WO 0103/6659 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.11.1999 US 166594 P 19.11.1999 US 444038 30.03.2000 US 539248 (71) Applicants: Novartis AG 4056 Basel (CH) BE CH CY DE DK ES FR FI GB GR IE IT LI LU MC NL PT SE  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. 1230 Wien (AT) AT	(72) Inventors: PIPPIG, Susanne, Dagmar San Francisco, CA 94122 (US) VERES, Gabor Palo Alto, CA 94303 (US) (74) Representative: Gros, Florent  Novartis AG 4002 Basel 4002 Basel (CH)