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EP 1 278 844 A2

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(88) Date of publication A3: 22.08.2002 (43) Date of publication: 29.01.2003 Bulletin 2003/05 (21) Application number: 01932827.7 (22) Date of filing: 01.05.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 14/72, C12N 15/63, C12N 5/10, C12P 21/00, C07K 16/28, G01N 33/68, C12Q 1/68, A61K 38/17 (86) International application number: PCT/US0114/050 (87) International publication number: WO 0108/3553 (08.11.2001 Gazette 2001/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.05.2000 US 201633 P 03.05.2000 US 201632 P 03.05.2000 US 201551 P 03.05.2000 US 201549 P 03.05.2000 US 201548 P 03.05.2000 US 201552 P 03.05.2000 US 201978 P 03.05.2000 US 201550 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)

(72) Inventors: PARODI, Luis, A. S-115 43 Stockholm (SE) LIND, Peter S-751 29 Uppsala (SE) SEJLITZ, Torsten S-112 34 Stockholm (SE) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)