(19)

(11)

EP 1 280 530 A1

(12)

(43) Date of publication: 05.02.2003 Bulletin 2003/06 (21) Application number: 01928355.5 (22) Date of filing: 17.04.2001

(51) International Patent Classification (IPC)7: A61K 31/505, A61K 31/48, A61K 31/47, A61K 31/445, A61K 31/40, A61P 43/00 (86) International application number: PCT/US0110/806 (87) International publication number: WO 0108/7308 (22.11.2001 Gazette 2001/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.04.2000 US 198960 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: ROBERTSON, David, W. Galesburg, MI 49053 (US) MCCALL, Robert, B. Kalamazoo, MI 49002 (US) MARSHALL, Robert, C. Mattawan, MI 49071 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)