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EP 1 280 824 A2

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(88) Date of publication A3: 18.07.2002 (43) Date of publication: 05.02.2003 Bulletin 2003/06 (21) Application number: 01931099.4 (22) Date of filing: 10.05.2001

(51) International Patent Classification (IPC)7: C07K 14/705, C12N 15/12, C12N 5/10, C07K 16/28, G01N 33/53, C12Q 1/68, C07K 19/00, C12N 15/62 (86) International application number: PCT/US0114/965 (87) International publication number: WO 0108/5788 (15.11.2001 Gazette 2001/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.05.2000 US 203305 P 23.05.2000 US 206526 P 25.05.2000 US 207092 P 25.05.2000 US 207033 P 25.05.2000 US 207093 P 07.07.2000 US 216893 P 04.08.2000 US 223245 P 04.10.2000 US 237873 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)

(72) Inventors: ROBERDS, Steven, L. Mattawan, MI 49071 (US) BENJAMIN, Christopher, W. Kalamazoo, MI 49009 (US) KARNOVSKY, Alla, M. Kalamazoo, MI 49009 (US) RUBLE, Cara, L. Paw Paw, MI (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)