(19)
(11) EP 1 280 930 A1

(12)

(43) Date of publication:
05.02.2003 Bulletin 2003/06

(21) Application number: 01930748.7

(22) Date of filing: 25.04.2001
(51) International Patent Classification (IPC)7C12Q 1/00, G01N 33/53, C12N 9/48, A61K 38/00, C07K 14/00, C07H 21/04
(86) International application number:
PCT/US0113/332
(87) International publication number:
WO 0108/3811 (08.11.2001 Gazette 2001/45)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 01.05.2000 US 201053 P

(71) Applicant: Merck & Co., Inc.
Rahway,New Jersey 07065-0907 (US)

(72) Inventors:
  • LI, Yueming
    Rahway, NJ 07065-0907 (US)
  • XU, Min
    Rahway, NJ 07065-0907 (US)
  • HUANG, Qian
    Rahway, NJ 07065-0907 (US)
  • GARDELL, Stephen
    Rahway, NJ 07065-0907 (US)

(74) Representative: Hiscock, Ian James 
European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road
Harlow,Essex CM20 2QR
Harlow,Essex CM20 2QR (GB)

   


(54) GAMMA SECRETASE SUBSTRATES AND IN VITRO ASSAYS