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(11)

EP 1 280 932 A1

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(43) Date of publication: 05.02.2003 Bulletin 2003/06 (21) Application number: 00967318.7 (22) Date of filing: 03.10.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, A61P 43/00, G01N 33/50 (86) International application number: PCT/US0027/430 (87) International publication number: WO 0209/0588 (14.11.2002 Gazette 2002/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: Fred Hutchinson Cancer Research Center Seattle, WA 98109 (US)	(72) Inventors: BEDALOV, Antonio Seattle, WA 98144 (US) NELSON, Melissa Dashiel Everett, WA 98201 (US) PADDISON, Patrick Oyster Bay, NY 11771 (US) FRIEND, Steve Seattle, WA 98144 (US) (74) Representative: Luderschmidt, Schüler & Partner GbR  Patentanwälte,John-F.-Kennedy-Strasse 4 65189 Wiesbaden 65189 Wiesbaden (DE)