(19)

(11)

EP 1 282 411 A1

(12)

(43) Date of publication: 12.02.2003 Bulletin 2003/07 (21) Application number: 01927380.4 (22) Date of filing: 02.03.2001

(51) International Patent Classification (IPC)7: A61K 31/05, A61K 31/66 (86) International application number: PCT/US0140/237 (87) International publication number: WO 0108/0849 (01.11.2001 Gazette 2001/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.04.2000 US 200028 P (71) Applicant: Charlotte-Mecklenburg Hosptial Authority doing business as Carolinas Medical Center Charlotte, NC 28232-2861 (US)	(72) Inventor: KENNEDY, Thomas, P. Charlotte, NC 28226 (US) (74) Representative: MacDougall, Donald Carmichael et al Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AE, Scotland Glasgow G1 3AE, Scotland (GB)