(19)

(11)

EP 1 282 441 A2

(12)

(88) Date of publication A3: 04.04.2002 (43) Date of publication: 12.02.2003 Bulletin 2003/07 (21) Application number: 01930475.7 (22) Date of filing: 30.04.2001

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 38/17, A61P 31/00, A61P 35/00, A61P 37/00 // C07K14/705, C07K16/28, C07K19/00 , A01K67:027 (86) International application number: PCT/US0111/735 (87) International publication number: WO 0108/5209 (15.11.2001 Gazette 2001/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.05.2000 US 203015 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46285 (US)	(72) Inventors: HEUER, Josef, Georg Indianapolis, IN 46231 (US) LIU, Jinqi Plainsboro, NJ 08536 (US) NA, Songqing Carmel, IN 46032 (US) SONG, Ho, Yeong Carmel, IN 46032 (US) YANG, Derek, Di Carmel, IN 46033 (US) (74) Representative: Kingsbury, Oliver William  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)