(19)

(11)

EP 1 282 626 A2

(12)

(88) Date of publication A3: 23.05.2002 (43) Date of publication: 12.02.2003 Bulletin 2003/07 (21) Application number: 01935329.1 (22) Date of filing: 10.05.2001

(51) International Patent Classification (IPC)7: C07D 498/18, C12P 17/18 (86) International application number: PCT/US0115/234 (87) International publication number: WO 0108/7884 (22.11.2001 Gazette 2001/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.05.2000 US 204828 P 14.07.2000 US 218176 P 22.11.2000 US 252968 P (71) Applicant: Kosan Biosciences, Inc. Hayward, CA 94545 (US)	(72) Inventors: Chu, Daniel Santa Clara, CA 95051 (US) Fardis, Maria San Carlos, CA 94070 (US) Khosla, Chaitan Palo Alto, CA 94306 (US) Reeves, Christopher Orinda, CA 94563 (US) Santi, Daniel San Francisco, CA 94111 (US) Schirmer, Andreas Hayward, CA 94544 (US) (74) Representative: Murphy, Colm Damien et al Boult Wade Tennant,Verulam Gardens,70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)