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EP 1 283 849 A2

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(88) Date of publication A3: 17.10.2002 (43) Date of publication: 19.02.2003 Bulletin 2003/08 (21) Application number: 01939361.0 (22) Date of filing: 23.05.2001

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 16/28, C12N 15/12, C12N 15/62, A61K 38/17, A61K 39/395, C12N 5/10, C12N 1/21 (86) International application number: PCT/US0116/766 (87) International publication number: WO 0109/0151 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.05.2000 US 207558 P (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)

(72) Inventors: HARDIMAN, Gerard, T. San Diego, CA 92128 (US) ROCK, Fernando, L. La Honda, CA 94020 (US) BAZAN, J., Fernando Palo Alto, CA 94301 (US) KASTELEIN, Robert, A. Redwood City, CA 94062 (US) HO, Stephen, W. K. Sunnyvale, CA 94087 (US) LIU, Yong-Jun Palo Alto, CA 94306 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)