(19)

(11)

EP 1 283 883 A1

(12)

(43) Date of publication: 19.02.2003 Bulletin 2003/08 (21) Application number: 01931884.9 (22) Date of filing: 21.05.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/85, C12N 15/86, C07K 14/47, C07K 16/18, C12Q 1/68, G01N 33/577, A61K 31/713, A61K 38/18, A01K 67/027 (86) International application number: PCT/GB0102/240 (87) International publication number: WO 0109/0354 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.05.2000 GB 0012186 (71) Applicant: THE UNIVERSITY OF LEEDS Leeds, LS2 9JT (GB)	(72) Inventors: MARKHAM, Alexander, Fred Leeds LS9 7TF (GB) JACKSON, Andrew, Peter Leeds LS9 7TF (GB) WOODS, Christopher, Geoffrey Leeds LS9 7TF (GB) (74) Representative: Harrison Goddard Foote  Belgrave Hall,Belgrave Street Leeds, LS2 8DD Leeds, LS2 8DD (GB)