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(11)

EP 1 283 884 A2

(12)

(88) Date of publication A3: 29.08.2002 (43) Date of publication: 19.02.2003 Bulletin 2003/08 (21) Application number: 01935420.8 (22) Date of filing: 11.05.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 15/62, C12N 5/10, C12N 9/00, C12N 15/86, G01N 33/50, C07H 15/24 (86) International application number: PCT/US0115/416 (87) International publication number: WO 0108/5944 (15.11.2001 Gazette 2001/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.05.2000 US 569327 (71) Applicant: MITOKOR San Diego, CA 92121 (US)

(72) Inventors: ANDERSON, Christen, M. Encinitas, CA 92024 (US) DAVIS, Robert, E. San Diego, CA 92130 (US) CLEVENGER, William Oceanside, CA 92056 (US) WILEY, Sandra, Eileen San Diego, CA 92122 (US) MILLER, Scott, W. San Marcos, CA 92069 (US) SZABO, Tomas, R. San Diego, CA 92103 (US) GHOSH, Soumitra, S. San Diego, CA 92129 (US) MOOS, Walter, H. Oakland, CA 94611 (US) PEI, Yazhong San Diego, CA 92130 (US) CARROLL, Amy, K. San Diego, CA 92117 (US) (74) Representative: Gowshall, Jonathan Vallance  FORRESTER & BOEHMERTPettenkoferstrasse 20-22 80336 München 80336 München (DE)