(19)

(11)

EP 1 284 732 A2

(12)

(88) Date of publication A3: 25.04.2002 (43) Date of publication: 26.02.2003 Bulletin 2003/09 (21) Application number: 01935516.3 (22) Date of filing: 15.05.2001

(51) International Patent Classification (IPC)7: A61K 31/437, A61P 1/04, A61P 1/00 (86) International application number: PCT/US0115/633 (87) International publication number: WO 0108/7305 (22.11.2001 Gazette 2001/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.05.2000 US 205308 P (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)	(72) Inventor: MANGEL, Allen Wayne,GlaxoSmithKline Research Triangle Park, NC 27709 (US) (74) Representative: Valentine, Jill Barbara et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)