(19)

(11)

EP 1 284 976 A2

(12)

(88) Date of publication A3: 31.01.2002 (43) Date of publication: 26.02.2003 Bulletin 2003/09 (21) Application number: 01944118.7 (22) Date of filing: 27.04.2001

(51) International Patent Classification (IPC)7: C07D 487/00 (86) International application number: PCT/US0113/798 (87) International publication number: WO 0108/1347 (01.11.2001 Gazette 2001/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.04.2000 US 559943 12.04.2001 US 833914 (71) Applicant: Abbott Laboratories Abbott Park, IL 60064-6050 (US)

(72) Inventors: SCHRIMPF, Michael, R. Grayslake, IL 60030 (US) TIETJE, Karin, R. Mundelein, IL 60060 (US) TOUPENCE, Richard, B. South Plainfield, NJ 07080 (US) JI, Jianguo Libertyville, IL 60048 (US) BASHA, Anwer Lake Forest, IL 60045 (US) BUNNELLE, William, H. Mundelein, IL 60060 (US) DAANEN, Jerome, F. Racine, WI 53405 (US) PACE, Jennifer, M. Grayslake, IL 60030 (US) SIPPY, Kevin, B. Antioch, IL 60002 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)