(19)

(11)

EP 1 285 081 A2

(12)

(88) Date of publication A3: 12.09.2002 (43) Date of publication: 26.02.2003 Bulletin 2003/09 (21) Application number: 01931977.1 (22) Date of filing: 30.05.2001

(51) International Patent Classification (IPC)7: C12N 15/88, C12N 5/10, C07K 16/28, C07K 7/06, C07K 7/08, C12P 21/00 (86) International application number: PCT/GB0102/396 (87) International publication number: WO 0109/2543 (06.12.2001 Gazette 2001/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.05.2000 GB 0013089 30.05.2000 GB 0013090 01.05.2001 US 287410 P (71) Applicant: ICH Productions Limited London WC1N JEH (GB)	(72) Inventor: HART, Stephen L.,Institute of Child Health London WC1N 1EH (GB) (74) Representative: Silveston, Judith et al ABEL & IMRAY20 Red Lion Street London, WC1R 4PQ London, WC1R 4PQ (GB)