(19)

(11)

EP 1 286 697 A2

(12)

(88) Date of publication A3: 16.05.2002 (43) Date of publication: 05.03.2003 Bulletin 2003/10 (21) Application number: 01932539.8 (22) Date of filing: 07.05.2001

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 35/00, A61K 31/00, A61K 38/00, G01N 33/50, A61K 49/00, A61P 3/04 (86) International application number: PCT/US0111/752 (87) International publication number: WO 0108/7335 (22.11.2001 Gazette 2001/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.05.2000 US 204897 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: BRYANT, Henry, Uhlman Indianapolis, IN 46250 (US) HEIMAN, Mark, Louis Indianapolis, IN 46250 (US) (74) Representative: Burnside, Ivan John et al Eli Lilly and Company LimitedLilly Research CentreErl Wood ManorSunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)