(19)
(11) EP 1 286 698 A1

(12)

(43) Date of publication:
05.03.2003 Bulletin 2003/10

(21) Application number: 01935670.8

(22) Date of filing: 18.05.2001
(51) International Patent Classification (IPC)7A61K 39/395, A61P 35/00, A61P 35/04, G01N 33/574
// (C07K16/24, 16:28)
(86) International application number:
PCT/US0116/058
(87) International publication number:
WO 0108/9565 (29.11.2001 Gazette 2001/48)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 19.05.2000 US 205757 P

(71) Applicant: THE UNITED STATES GOVERNMENTas represented byTHE DEPARTMENTOF HEALTH AND HUMAN SERVICES
Rockville, MD 20852-3804 (US)

(72) Inventors:
  • MURPHY, William, J.
    Frederick, MD 21701 (US)
  • OPPENHEIM, Joost, J.
    Bethesda, MD 20817 (US)
  • SALCEDO, Rosalba
    Frederick, MD 21702 (US)

(74) Representative: Eisenführ, Speiser & Partner 
Arnulfstrasse 25
80335 München
80335 München (DE)

   


(54) METHODS FOR REDUCING TUMOR GROWTH AND METASTASIS BY INHIBITING MCP-1 ACTIVITY