(19)
(11) EP 1 286 982 A2

(12)

(88) Date of publication A3:
06.06.2002

(43) Date of publication:
05.03.2003 Bulletin 2003/10

(21) Application number: 01941787.2

(22) Date of filing: 01.06.2001
(51) International Patent Classification (IPC)7: C07D 311/58, A61K 31/35, C07C 257/18
(86) International application number:
PCT/US0117/765
(87) International publication number:
WO 0109/4333 (13.12.2001 Gazette 2001/50)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 02.06.2000 US 208762 P

(71) Applicant: Eli Lilly & Company
Indianapolis, IN 46285 (US)

(72) Inventors:
  • ANTOINE, Luc
    B-3401 Landen (BE)
  • BOUQUEL, Pascal
    F-55600 Breux (FR)
  • BORGHESE, Alfio
    B-1470 Baisy-Thy (BE)
  • FISHER, Matthew
    Mooresville, IN 46158 (US)
  • GORISSEN, Hugo
    B-1390 Grez-Doiceau (BE)
  • JAKUBOWSKI, Joseph, A.
    Indianapolis, IN 46208 (US)
  • KHAU, Vien, V.
    Carmel, IN 46038 (US)
  • MARTINELLI, Michael
    Zionsville, IN 46077 (US)
  • MERSCHAERT, Alain
    B-7850 Petit-Enghien (BE)
  • PAAL, Michael
    22335 Hamburg (DE)
  • RUHTER, Gerd
    21129 Hamburg (DE)
  • RYPENS, Carine
    F-91120 Palaiseau (FR)
  • SCHOTTEN, Theo
    21444 Vierhofen (DE)
  • STENZEL, Wolfgang
    21465 Reinbek (DE)
  • VAN HOECK, Jean-Pierre
    B-1475 Chastre (BE)

(74) Representative: Mallalieu, Catherine Louise et al
D. Young & Co.,21 New Fetter Lane
London EC4A 1DA
London EC4A 1DA (GB)

   


(54) PROCESS FOR THE PREPARATION OF BENZOYL SUBSTITUTED BICYLIC COMPOUNDS AND CHIRAL BNEZOPYRAN DERIVATIVES