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(11)

EP 1 289 940 A2

(12)

(88) Date of publication A3: 04.07.2002 (43) Date of publication: 12.03.2003 Bulletin 2003/11 (21) Application number: 01938986.5 (22) Date of filing: 24.05.2001

(51) International Patent Classification (IPC)7: C07C 271/28, A61K 31/27, A61K 31/17, A61K 31/18, A61P 25/00, C07C 271/12, C07C 271/24, C07C 271/30, C07C 275/28, C07C 275/18, C07C 335/16, C07C 311/19 (86) International application number: PCT/US0110/832 (87) International publication number: WO 0109/2213 (06.12.2001 Gazette 2001/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.05.2000 EP 00500109 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46285 (US)

(72) Inventors: COLLADO-CANO, Ivan,c/o Lilly, S.A. E-28108 Alcobendas-Madrid (ES) GONZALEZ-GARCIA, Rosario,c/o Lilly, S.A. E-28108 Alcobendas-Madrid (ES) LOPEZ DE URALDE-GARMENDIA, B.,c/o Lilly, S.A. E-28108 Alcobendas-Madrid (ES) (74) Representative: Kingsbury, Oliver William  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)