(19)
(11) EP 1 290 154 A2

(12)

(88) Date of publication A3:
27.12.2002

(43) Date of publication:
12.03.2003 Bulletin 2003/11

(21) Application number: 01913217.4

(22) Date of filing: 01.03.2001
(51) International Patent Classification (IPC)7C12N 15/10, C12N 15/11, C12N 15/63, C12N 15/86, C12N 5/10, C12N 9/00, C12Q 1/68, A61P 43/00
(86) International application number:
PCT/US0106/615
(87) International publication number:
WO 0106/4956 (07.09.2001 Gazette 2001/36)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 01.03.2000 US 186248 P

(71) Applicant: Amgen Inc.
Thousand Oaks, CA 91320-1799 (US)

(72) Inventors:
  • MARSHALL, William, S.
    Boulder, CO 80303 (US)
  • KHVOROVA, Anastasia
    Boulder, CO 80305 (US)
  • JAYASENA, Sumedha
    Boulder, CO 80301 (US)

(74) Representative: Richardson, Kate et al
Forrester & Boehmert,Pettenkoferstrasse 20-22
80336 München
80336 München (DE)

   


(54) THE IDENTIFICATION AND USE OF EFFECTORS AND ALLOSTERIC MOLECULES FOR THE ALTERATION OF GENE EXPRESSION