(19)

(11)

EP 1 290 206 A2

(12)

(88) Date of publication A3: 05.12.2002 (43) Date of publication: 12.03.2003 Bulletin 2003/11 (21) Application number: 01944672.3 (22) Date of filing: 08.06.2001

(51) International Patent Classification (IPC)7: C12N 15/861 (86) International application number: PCT/US0140/901 (87) International publication number: WO 0109/4605 (13.12.2001 Gazette 2001/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.06.2000 US 590810 (71) Applicant: University of Florida Gainesville,Florida 32611-5500 (US)

(72) Inventors: ZOLOTUKHIN, Sergei Gainesville, FL 32607 (US) KALRA, Satya, P. Gainesville, FL 32605 (US) MOLDAWER, Lyle, L. Gainesville, FL 32605 (US) MUZYCZKA, Nicholas Gainesville, FL 32608 (US) HAUSWIRTH, William, W. Gainesville, FL 32608 (US) KALRA, Pushpa, S. Gainesville, FL 32605 (US) (74) Representative: Glawe, Delfs, Moll & Partner  PatentanwälteRothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)