(19)

(11)

EP 1 292 284 A2

(12)

(88) Date of publication A3: 03.10.2002 (43) Date of publication: 19.03.2003 Bulletin 2003/12 (21) Application number: 01942131.2 (22) Date of filing: 08.06.2001

(51) International Patent Classification (IPC)7: A61K 9/127, C12N 15/88, A61K 9/107 (86) International application number: PCT/US0118/657 (87) International publication number: WO 0109/3836 (13.12.2001 Gazette 2001/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.06.2000 US 210925 P (71) Applicant: Boulikas, Teni Mountain View, CA 94043 (US)	(72) Inventor: Boulikas, Teni Mountain View, CA 94043 (US) (74) Representative: Gates, Marie Christina Esther et al c/o Tomkins & Co.5 Dartmouth Road Dublin 6 Dublin 6 (IE)