(19)

(11)

EP 1 292 318 A2

(12)

(88) Date of publication A3: 03.01.2003 (43) Date of publication: 19.03.2003 Bulletin 2003/12 (21) Application number: 01918277.3 (22) Date of filing: 01.03.2001

(51) International Patent Classification (IPC)7: A61K 35/54, A61K 38/43 (86) International application number: PCT/US0106/467 (87) International publication number: WO 0106/4936 (07.09.2001 Gazette 2001/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.03.2000 US 186230 P (71) Applicant: Texas Tech University Health Sciences Center Lubbock, TX 79409-2007 (US)	(72) Inventors: PRIEN, Samuel, D. Shallowater, TX 79363 (US) JOHNSON, Dustie Midland, TX 79705-6502 (US) (74) Representative: W.P. THOMPSON & CO.  Eastcheap HouseCentral Approach Letchworth,Hertfordshire SG6 3DS Letchworth,Hertfordshire SG6 3DS (GB)