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EP 1 292 323 A1

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(43) Date of publication: 19.03.2003 Bulletin 2003/12 (21) Application number: 00932586.1 (22) Date of filing: 19.05.2000

(51) International Patent Classification (IPC)7: A61K 38/17, G01N 33/68, A61K 39/395, A61K 31/7088, A61P 17/02 (86) International application number: PCT/US0013/725 (87) International publication number: WO 0108/9556 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)	(72) Inventors: ROBERTS, Anita, B. Bethesda, MD 20817 (US) ASHCROFT, Gillian, S. Nr. Ormskirk,Lancashire L40 OSG (GB) RUSSO, Angelo Bethesda, MD 20817 (US) MITCHELL, James, B. Damascus, MD 20872 (US) DENG, Chuxia Bethesda, MD 20817 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)