(19)

(11)

EP 1 292 571 A2

(12)

(88) Date of publication A3: 23.05.2002 (43) Date of publication: 19.03.2003 Bulletin 2003/12 (21) Application number: 01937169.9 (22) Date of filing: 23.05.2001

(51) International Patent Classification (IPC)7: C07C 311/05, A61K 31/18, A61P 25/18, A61P 25/28 (86) International application number: PCT/US0110/829 (87) International publication number: WO 0109/4306 (13.12.2001 Gazette 2001/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.06.2000 US 209675 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: KNOBELSDORF, James, Allen Noblesville, IN 46060 (US) ZARRINMAYEH, Hamideh Carmel, IN 46032 (US) (74) Representative: Kingsbury, Oliver William  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)