(19)

(11)

EP 1 294 679 A1

(12)

(43) Date of publication: 26.03.2003 Bulletin 2003/13 (21) Application number: 01943489.3 (22) Date of filing: 08.06.2001

(51) International Patent Classification (IPC)7: C07C 255/44, C07C 255/29, C07C 271/24, C07C 311/20, C07D 317/60, C07D 307/85, C07D 333/32, A61K 31/277, A61K 31/36, A61K 31/343, A61K 31/381, A61P 19/10, A61P 9/00 (86) International application number: PCT/EP0106/541 (87) International publication number: WO 0109/6285 (20.12.2001 Gazette 2001/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.06.2000 EP 00112577 (71) Applicant: F. HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventors: GABRIEL, Tobias 79539 Loerrach (DE) PECH, Michael 79258 Hartheim (DE) RODRIGUEZ SARMIENTO, Rosa Maria CH-4055 Basle (CH) (74) Representative: Witte, Hubert, Dr. et al 124 Grenzacherstrasse 4070 Basel 4070 Basel (CH)