(19)
(11) EP 1 294 869 A2

(12)

(88) Date of publication A3:
23.05.2002

(43) Date of publication:
26.03.2003 Bulletin 2003/13

(21) Application number: 01944583.2

(22) Date of filing: 14.06.2001
(51) International Patent Classification (IPC)7: C12N 15/10, C12Q 1/68
(86) International application number:
PCT/US0119/367
(87) International publication number:
WO 0109/6551 (20.12.2001 Gazette 2001/51)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 14.06.2000 US 594459
30.09.2000 US 677584

(71) Applicant: DIVERSA CORPORATION
San Diego, CA 92121 (US)

(72) Inventor:
  • SHORT, Jay M.
    Rancho Santa Fe, CA 92067-7214 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING