(19)

(11)

EP 1 294 875 A2

(12)

(88) Date of publication A3: 05.12.2002 (43) Date of publication: 26.03.2003 Bulletin 2003/13 (21) Application number: 01946410.6 (22) Date of filing: 13.06.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 5/10, C07K 16/18, C12Q 1/68, G01N 33/53, A61K 48/00, A61K 31/00, A61K 33/00, A61K 38/17, A61K 39/395, A61K 35/12, A01K 67/027 (86) International application number: PCT/US0119/246 (87) International publication number: WO 0109/6391 (20.12.2001 Gazette 2001/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.06.2000 US 211454 P (71) Applicant: Agensys, Inc. Santa Monica, CA 90404 (US)

(72) Inventors: FARIS, Mary Los Angeles, CA 90077 (US) HUBERT, Rene, S. Los Angeles, CA 90026 (US) AFAR, Daniel, E., H. Brisbane, CA 94005 (US) LEVIN, Elana Los Angeles, CA 90034 (US) MITCHELL, Steven, Chappell Santa Monica, CA 90405 (US) RAITANO, Arthur, B. Los Angeles, CA 90064 (US) JAKOBOVITS, Aya Beverly Hills, CA 90210 (US) (74) Representative: Gates, Marie Christina Esther  c/o Tomkins & Co.5 Dartmouth Road Dublin 6 Dublin 6 (IE)