(19)

(11)

EP 1 294 887 A1

(12)

(43) Date of publication: 26.03.2003 Bulletin 2003/13 (21) Application number: 01909021.6 (22) Date of filing: 09.02.2001

(51) International Patent Classification (IPC)7: C12N 15/17, C07K 14/62, C07K 14/64, C07K 16/26, C12P 21/02 (86) International application number: PCT/US0104/199 (87) International publication number: WO 0106/8862 (20.09.2001 Gazette 2001/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.03.2000 US 523346 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: HOLLOWAY, James, L. Seattle, WA 98115 (US) LOK, Si Seattle, WA 98107 (US) JASPERS, Stephen, R. Edmonds, WA 98026 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)