(19)

(11)

EP 1 294 928 A1

(12)

(43) Date of publication: 26.03.2003 Bulletin 2003/13 (21) Application number: 01943488.5 (22) Date of filing: 08.06.2001

(51) International Patent Classification (IPC)7: C12Q 1/48 (86) International application number: PCT/EP0106/520 (87) International publication number: WO 0109/4621 (13.12.2001 Gazette 2001/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.06.2000 EP 00112479 09.06.2000 EP 00112345 (71) Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GmbH 55218 Ingelheim am Rhein (DE)	(72) Inventors: JENUWEIN, Thomas A-1030 Wien (AT) REA, Stephen Headford,County Galway (IE) O'CARROLL, Dúnal Greystones,County Wicklow (IE) (74) Representative: Hammann, Heinz, Dr. et al c/o Boehringer Ingelheim GmbH,CD Patents 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)