| (19) |
 |
|
(11) |
EP 1 295 605 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
29.10.2003 Bulletin 2003/44 |
| (43) |
Date of publication A2: |
|
26.03.2003 Bulletin 2003/13 |
| (22) |
Date of filing: 19.08.1999 |
|
| (51) |
International Patent Classification (IPC)7: A61K 38/29, A61P 19/08
// (A61K38/29, 33:06),(A61K38/29, 31:59) |
|
| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
Designated Extension States: |
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AL LT LV MK RO SI |
| (30) |
Priority: |
19.08.1998 US 97151
10.09.1998 US 99746
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
99942350.2 / 1059933 |
| (71) |
Applicant: ELI LILLY AND COMPANY |
|
Indianapolis, IN 46285 (US) |
|
| (72) |
Inventor: |
|
- Hock, Janet M.
Indianapolis, IN 46250 (US)
|
| (74) |
Representative: Fisher, Adrian John et al |
|
CARPMAELS & RANSFORD 43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB) |
|
| |
|
| (54) |
Method of increasing bone toughness and stiffness and reducing fractures |
(57) The invention relates to a method for increasing the toughness and/or stiffness of
bone and/or reducing the likelihood and/or severity of bone fracture by administering
a parathyroid hormone. The method can be employed to increase toughness or stiffness
of bone at a site of a potential or actual trauma, such as the hip or spine of a person
at risk of or suffering osteoporosis. The method of the invention can reduce the incidence
of vertebral fracture, reduce the incidence of multiple vertebral fractures, reduce
the severity of vertebral fracture, and/or reduce the incidence of non-vertebral fracture.