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EP 1 296 942 A1

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(43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 01943189.9 (22) Date of filing: 21.06.2001

(51) International Patent Classification (IPC)7: C07C 275/24, C07C 275/28, C07C 237/20, C07C 237/32, C07D 209/48, C07D 213/36, C07D 277/62, A61K 31/166, A61K 31/167, A61K 31/17, A61K 31/429, A61K 31/4035, A61K 31/44, A61P 3/04, A61P 3/10 (86) International application number: PCT/DK0100/435 (87) International publication number: WO 0200/0612 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.06.2000 DK 200000984 17.11.2000 DK 200001734 (71) Applicant: Novo Nordisk A/S 2880 Bagsvaerd (DK)

(72) Inventors: JOERGENSEN, Anker, Steen DK-2100 K benhavn (DK) CHRISTENSEN, Inge, Thoeger DK-2800 Lyngby (DK) KODRA, Janos, Tibor DK-2100 K benhavn (DK) MADSEN, Peter DK-2880 Bagsv rd (DK) BEHRENS, Carsten DK-2200 K benhavn N (DK) SAMS, Christian DK-1973 Frederiksberg C (DK) LAU, Jesper DK-3520 Farum (DK) (74) Representative: Stahr, Pia et al Novo Nordisk A/S,Corporate Patents,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)