(19)

(11)

EP 1 296 980 A1

(12)

(43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 01938400.7 (22) Date of filing: 08.06.2001

(51) International Patent Classification (IPC)7: C07D 417/12, A61K 31/425, A61K 31/44, A61P 3/10 (86) International application number: PCT/GB0102/567 (87) International publication number: WO 0109/4344 (13.12.2001 Gazette 2001/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.06.2000 GB 0014006 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9GS (GB)	(72) Inventors: CRAIG, Andrew Simon,SaxoSmithKline Tonbridge,Kent TN11 9AN (GB) HO, Tim Chien Ting,GlaxoSmithKline Tonbridge,Kent TN11 9AN (GB) (74) Representative: Rutter, Keith, Dr.  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)