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(11)

EP 1 297 117 A1

(12)

(43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 00942940.8 (22) Date of filing: 20.06.2000

(51) International Patent Classification (IPC)7: C12N 9/64, C12N 15/70, C12N 15/57, C12N 15/79, C12N 15/85, A61K 31/713, A61K 38/48 (86) International application number: PCT/US0016/848 (87) International publication number: WO 0109/8476 (27.12.2001 Gazette 2001/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) NI, Jian Rockville, MD 20853 (US) SHI, Yanggu Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)