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EP 1 297 129 A2

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(88) Date of publication A3: 16.01.2003 (43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 01939529.2 (22) Date of filing: 24.05.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/47, A61K 38/17, A61K 39/395, G01N 33/53, G01N 33/68, C12Q 1/68 (86) International application number: PCT/US0117/158 (87) International publication number: WO 0109/0156 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.05.2000 US 579240 10.10.2000 US 686347 14.03.2001 US 275980 P 23.05.2001 US 864921 (71) Applicant: The Burnham Institute La Jolla, CA 92037 (US)

(72) Inventors: REED, John, C. Rancho Santa Fe, CA 92067 (US) PIO, Frederick, F. Vancouver, British Colombia V5L 2J4 (CA) GODZIK, Adam San Diego, CA 92129 (US) STEHLIK, Christian San Diego, CA 92122 (US) DAMIANO, Jason, S. La Jolla, CA 92037-5900 (US) LEE, Sug Hyung Seoul 137-950 (US) OLIVEIRA, Vasco A. M. San Diego, CA 92122 (US) HAYASHI, Hideki Nagasaki City 852-8123 (JP) PAWLOWSKI, Krzysztof 21745 Malmö (SE) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)