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EP 1 297 137 A2

(12)

(88) Date of publication A3: 03.01.2003 (43) Date of publication: 02.04.2003 Bulletin 2003/14 (21) Application number: 01952197.0 (22) Date of filing: 22.06.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 16/28, C12N 5/10, C12N 15/62, A61K 38/17, C12Q 1/68, G01N 33/68, A61K 31/7088, A61K 39/395 (86) International application number: PCT/US0120/038 (87) International publication number: WO 0200/0727 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.06.2000 US 213630 P 13.04.2001 US 283813 P (71) Applicant: BIOGEN, INC. CambridgeMassachusetts 02142 (US)	(72) Inventors: CARULLI, John, P. Southborough, MA 01772 (US) LUKASHIN, Alexander, V. Charlestown, MA 02129 (US) KILBURN, Daniel, R. Lexington, MA 02420 (US) MATHUR, Punam Cambridge, MA 02140 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)